CURRENT RESEARCH
The RENOKINE™ I IP-10 and MIG biplex assay system is a clinical tool designed by Renovar Inc. with the expectation that it will aid clinicians in diagnosing the cryptic occurrence of acute injury in patients who have newly-transplanted renal allografts. The assay enjoys the advantage of assessing whole kidney function because it measures biomarkers in the urine of transplantation patients, a fluid that drains the entire organ.

As a biological medium, urine is notoriously harsh and variable, a reality that until recently has thwarted attempts at biochemical and molecular analysis. The singular advantage of RENOKINE™ I is its patented Buffering System that allows the user to quantify urinary protein with unprecedented sensitivity, specificity, and reproducibility. Renovar's Sample Diluent normalizes the extreme ranges in pH and salt concentration present in urine samples while a Calibration Diluent enables complex antibody-protein reactions to occur within the incubation.  

POTENTIAL RESEARCH APPLICATIONS

• Chronic kidney disease
• Contrast nephropathy
• Lupus nephritis
• Kidney vasculitis
• Cytokine kinetics
• Serum viral antibody detection
• Other kidney-related diseases 

CUSTOM ASSAY AND STUDY SERVICES
Our goal at Renovar is to work collaboratively to help you achieve your research goals as quickly, easily and cost-effectively as possible. Our scientists can provide start-to-finish support for your research study, including biomarker selection and assay panel development, study design and data analysis. We also provide testing services on samples you provide, creating even greater time-savings and efficiency for you and your lab.

Renovar's proprietary portfolio of more than 20 protein biomarkers can be used in a broad range of research applications and with a number of detection platforms, including the proven Luminex™ multiplexing system. 

Please contact us to discuss how we can help you meet your most important research needs.

1. Hu HZ, Aizenstein BD, Puchalski A, Burmania JA, Hamawy MM, Knechtle SJ. "Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction." American Journal of Transplantation 2004 4:432-7.
2. Kanmaz T, Feng P, Torrealba J, Kwan J, Fechner JH, Schultz JM, Dong Y, Kim HT, Dar W, Hamawy MM, Knechtle SJ, Hu HZ. "Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine. Transplantation 2004 78:1002-7.